Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.

doi:10.1053/j.gastro.2011.04.001

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Article

Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.

Gastroenterology - 1 Jul 2011

Lucena M Isabel, Molokhia Mariam, Shen Yufeng, Urban Thomas J, Aithal Guruprasad P, Andrade Raúl J, Day Christopher P, Ruiz-Cabello Francisco, Donaldson Peter T, Stephens Camilla, Pirmohamed Munir, Romero-Gomez Manuel, Navarro Jose Maria, Fontana Robert J, Miller Michael, Groome Max, Bondon-Guitton Emmanuelle, Conforti Anita, Stricker Bruno H C, Carvajal Alfonso, Ibanez Luisa, Yue Qun-Ying, Eichelbaum Michel, Floratos Aris, Pe'er Itsik, Daly Mark J, Goldstein David B, Dillon John F, Nelson Matthew R, Watkins Paul B, Daly Ann K

Abstract excerpt

BACKGROUND & AIMS: Drug-induced liver injury (DILI), especially from antimicrobial agents, is an important cause of serious liver disease. Amoxicillin-clavulanate (AC) is a leading cause of idiosyncratic DILI, but little is understood about genetic susceptibility to this adverse reaction. METHODS: We performed a genome-wide association study using 822,927 single nucleotide polymorphism (SNP) markers from 201...

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Identifiers

PMID: 21570397
DOI: 10.1053/j.gastro.2011.04.001
PMCID: PMC3129430

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PTPN22

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Source receipt: pubmed, retrieved 7 Sept 2026.

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