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Article

The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase.

Nature - 4 Nov 1993

Li R, Havel C, Watson J A, Murray A W

Abstract excerpt

The mad2-1 mutation inactivates the cell-cycle feedback control that prevents budding yeast cells from leaving mitosis until spindle assembly is complete. The gene product of MAD2 shows significant sequence similarity to the alpha-subunit of prenyltransferases. Here we isolate a new temperature-sensitive mad2 mutant, mad2-2ts, and find that Mad2p is required for the membrane association of Ypt1p and Sec4p, two...

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PMID: 8232541
DOI: 10.1038/366082a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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