The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase.

doi:10.1038/366082a0

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Article

The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase.

Nature - 4 Nov 1993

Li R, Havel C, Watson J A, Murray A W

Abstract excerpt

The mad2-1 mutation inactivates the cell-cycle feedback control that prevents budding yeast cells from leaving mitosis until spindle assembly is complete. The gene product of MAD2 shows significant sequence similarity to the alpha-subunit of prenyltransferases. Here we isolate a new temperature-s...

Topics

Calcium-Binding Proteins
Carrier Proteins
Cell Cycle Proteins
Crosses, Genetic
Fungal Proteins
GTP-Binding Proteins
Mad2 Proteins
Membrane Proteins
Molecular Sequence Data
Mutation
Nuclear Proteins
Protein Prenylation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Transferases
rab GTP-Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 8232541
DOI: 10.1038/366082a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8232541-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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