Article
PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2016
Jacobs Daniel I, Qin Qin, Lerro Michael C, Fu Alan, Dubrow Robert, Claus Elizabeth B, DeWan Andrew T, Wang Guilin, Lin Haifan, Zhu Yong
Abstract excerpt
BACKGROUND: PIWI-interacting RNAs (piRNAs), the largest class of noncoding RNAs in mammals, cooperate with PIWI proteins to safeguard the genome from insertional mutations during germline development. Although a growing number of studies have linked the PIWI-piRNA pathway to carcinogenesis, the role of piRNAs in glioma has not been explored. METHODS: Utilizing directly measured and imputed genotypes from the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.