Article
POT1 Regulates Proliferation and Confers Sexual Dimorphism in Glioma.
Cancer research - 15 May 2021
Jalali Ali, Yu Kwanha, Beechar Vivek, Bosquez Huerta Navish A, Grichuk Anthony, Mehra Deepika, Lozzi Brittney, Kong Kathleen, Scott Kenneth L, Rao Ganesh, Bainbridge Matthew N, Bondy Melissa L, Deneen Benjamin
Abstract excerpt
Germline POT1 mutations are found in a spectrum of cancers and confer increased risk. Recently, we identified a series of novel germline POT1 mutations that predispose carrier families to the development of glioma. Despite these strong associations, how these glioma-associated POT1 mutations contribute to glioma tumorigenesis remains undefined. Here we show that POT1-G95C increases proliferation in...
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