Article
Deciphering the 8q24.21 association for glioma.
Human molecular genetics - 1 Jun 2013
Enciso-Mora Victor, Hosking Fay J, Kinnersley Ben, Wang Yufei, Shete Sanjay, Zelenika Diana, Broderick Peter, Idbaih Ahmed, Delattre Jean-Yves, Hoang-Xuan Khe, Marie Yannick, Di Stefano Anna Luisa, Labussière Marianne, Dobbins Sara, Boisselier Blandine, Ciccarino Pietro, Rossetto Marta, Armstrong Georgina, Liu Yanhong, Gousias Konstantinos, Schramm Johannes, Lau Ching, Hepworth Sarah J, Strauch Konstantin, Müller-Nurasyid Martina, Schreiber Stefan, Franke Andre, Moebus Susanne, Eisele Lewin, Forsti Asta, Hemminki Kari, Tomlinson Ian P, Swerdlow Anthony, Lathrop Mark, Simon Matthias, Bondy Melissa, Sanson Marc, Houlston Richard S
Abstract excerpt
We have previously identified tagSNPs at 8q24.21 influencing glioma risk. We have sought to fine-map the location of the functional basis of this association using data from four genome-wide association studies, comprising a total of 4147 glioma cases and 7435 controls. To improve marker density across the 700 kb region, we imputed genotypes using 1000 Genomes Project data and high-coverage sequencing data...
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