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PGC1α downregulation and glycolytic phenotype in thyroid cancer

1 Jan 2019

Abstract excerpt

Increased aerobic glycolysis portends an unfavorable prognosis in thyroid cancer. The metabolic reprogramming likely results from altered mitochondrial activity and may promote cancer progression. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) plays a pivotal role in mitochondrial biogenesis and function. In the present study, we aimed to evaluate the clinicopathological significance of PGC1α...

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PMID: 31333799
DOI: 10.7150/jca.30018

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