Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells.

Oncogene - 8 Jul 2010

Favre C, Zhdanov A, Leahy M, Papkovsky D, O'Connor R

Abstract excerpt

The insulin-like growth factor (IGF-I) signalling pathway is essential for metabolism, cell growth and survival. It induces expression of the mitochondrial pyrimidine nucleotide carrier 1 (PNC1) in transformed cells, but the consequences of this for cell phenotype are unknown. Here we show that P...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Cell Respiration
Share to Glycolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

Share to Mesoderm

Share to Mitochondrial Membrane Transport Proteins

Share to Mitochondrial Proteins

Share to Neoplasm Invasiveness

Source

Identifiers

PMID: 20453889
DOI: 10.1038/onc.2010.146

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20453889-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells.PMID 20453889Read ↗

Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in CancerSemantic proximity Read ↗

Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and MetastasisSemantic proximity Read ↗

PGC1s and Beyond: Disentangling the Complex Regulation of Mitochondrial and Cellular MetabolismSemantic proximity Read ↗

The Role of PGC1α in Cancer Metabolism and its Therapeutic ImplicationsSemantic proximity Read ↗

Mitochondrial determinants of cancer health disparities.Semantic proximity Read ↗

CHCHD4 regulates a proliferation-EMT switch in tumour cells, through respiratory complex I mediated metabolismSemantic proximity Read ↗

Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cellsSemantic proximity Read ↗

Mitochondrial Fusion Suppresses Pancreatic Cancer Growth via Reduced Oxidative MetabolismSemantic proximity Read ↗

Posttranslational regulation of PGC‐1α and its implication in cancer metabolismSemantic proximity Read ↗

Functional linkage between mitochondrial electron transport, glycolysis, and AMP-activated protein kinase signaling underlying cancer cell survivalSemantic proximity Read ↗

Mitochondrial VDAC1 Silencing Leads to Metabolic Rewiring and the Reprogramming of Tumour Cells into Advanced Differentiated StatesSemantic proximity Read ↗

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.