Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma

25 Jan 2023

Abstract excerpt

Radiotherapy is a major component of standard-of-care treatment for gliomas, the most prevalent type of brain tumor. However, resistance to radiotherapy remains a major concern. Identification of mechanisms governing radioresistance in gliomas could reveal improved therapeutic strategies for treating patients. Here, we report that mitochondrial metabolic pathways are suppressed in radioresistant gliomas through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Mitochondrial Function and Pathology
Share to Peroxisome Proliferator-Activated Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36696363
DOI: 10.1158/0008-5472.can-22-3083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in GliomaPMID 36696363Read ↗

High PGC-1α Expression as a Poor Prognostic Indicator in Intracranial GliomaSemantic proximity Read ↗

SMYD2 induced PGC1α methylation promotes stemness maintenance of glioblastoma stem cellsSemantic proximity Read ↗

Unraveling Mitochondrial Determinants of Tumor Response to Radiation TherapySemantic proximity Read ↗

CPT1A Mediates Radiation Sensitivity in Colorectal CancerSemantic proximity Read ↗

Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and MetastasisSemantic proximity Read ↗

Glioblastomas: Hijacking Metabolism to Build a Flexible Shield for Therapy ResistanceSemantic proximity Read ↗

The interplay of mitochondrial dysfunction and altered metabolic pathways in glioblastomaSemantic proximity Read ↗

The Role of PGC1α in Cancer Metabolism and its Therapeutic ImplicationsSemantic proximity Read ↗

Mitochondrial Dysfunction: Effects and Therapeutic Implications in Cerebral Gliomas.Semantic proximity Read ↗

Posttranslational regulation of PGC‐1α and its implication in cancer metabolismSemantic proximity Read ↗

Stress Response Leading to Resistance in Glioblastoma—The Need for Innovative Radiotherapy (iRT) ConceptsSemantic proximity Read ↗

Bioenergetics Pathways and Therapeutic Resistance in Gliomas: Emerging Role of MitochondriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.