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TFAP2C is a key regulator of intrauterine trophoblast cell invasion and deep hemochorial placentation

3 Dec 2024

Abstract excerpt

Transcription factor AP-2 gamma (TFAP2C) has been identified as a key regulator of the trophoblast cell lineage and hemochorial placentation. The rat possesses deep placentation characterized by extensive intrauterine trophoblast cell invasion, which resembles human placentation. Tfap2c is expressed in multiple trophoblast cell lineages, including invasive trophoblast cells situated within the uterine-placental...

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PMID: 39625795
DOI: 10.1172/jci.insight.186471

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