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Article

Distribution of the <i>titf2/foxe1</i> gene product is consistent with an important role in the development of foregut endoderm, palate, and hair

13 Jun 2002

Abstract excerpt

Titf2/foxe1 is a forkhead domain-containing gene expressed in the foregut, in the thyroid, and in the cranial ectoderm of the developing mouse. Titf2 null mice exhibit cleft palate and either a sublingual or completely absent thyroid gland. In humans, mutations of the gene encoding for thyroid transcription factor-2 (TTF-2) result in the Bamforth syndrome, characterized by thyroid agenesis, cleft palate, spiky...

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PMID: 12203737
DOI: 10.1002/dvdy.10118

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