Article
Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.
BMC cell biology - 18 Jan 2007
George Manju, Ying GuoGuang, Rainey Mark A, Solomon Aharon, Parikh Pankit T, Gao Qingshen, Band Vimla, Band Hamid
Abstract excerpt
BACKGROUND: The four highly homologous human EHD proteins (EHD1-4) form a distinct subfamily of the Eps15 homology domain-containing protein family and are thought to regulate endocytic recycling. Certain members of this family have been studied in different cellular contexts; however, a lack of concurrent analyses of all four proteins has impeded an appreciation of their redundant versus distinct functions....
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