Article
Dose regimens for Chinese adult liver transplant recipients according to the genetic polymorphisms of CYP2C9, CYP2C19, and CYP3A5 in recipients and donors.
International journal of clinical pharmacology and therapeutics - 1 Aug 2016
Zhu Liqin, Liao Shasha, Wang Nan, Ge Tingyue, Yang Jianwei, Xu Gaoqi, Wang Jianhai, Li Keqiu, Li Guang
Abstract excerpt
OBJECTIVE: Genetic polymorphisms of the P450 2C9 enzyme (CYP2C9), CYP2C19 and CYP3A5 gene are known to affect the metabolism of many drugs applied in liver transplant recipients, such as warfarin, voriconazole, and tacrolimus. The aim of this study was to recommend dose regimens for the liver recipients based on CYP2C9, CYP2C19, and CYP3A5 genotypic combinations of liver transplant recipients and their donors....
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