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Article

The importance of CYP2C19 genotype in tacrolimus dose optimization when concomitant with voriconazole in heart transplant recipients.

British journal of clinical pharmacology - 1 Oct 2022

Huang Xiao, Zhou Ying, Zhang Jing, Xiang Hongping, Mei Hao, Liu Li, Tong Lu, Zeng Fang, Huang Yifei, Zhou Hong, Zhang Yu

Abstract excerpt

AIMS: Voriconazole remains the mainstay for the treatment of invasive fungal infections in heart transplant patients and can significantly increase tacrolimus exposure because of drug-drug interaction (DDI). However, the magnitude of this DDI is highly variable and difficult to predict. The purpose of this study was to present the characteristics of the DDI between tacrolimus and voriconazole, and further...

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PMID: 35508605
DOI: 10.1111/bcp.15385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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The importance of CYP2C19 genotype in tacrolimus dose optimization when concomitant with voriconazole in heart transplant recipients.PMID 35508605Read ↗

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Cohort Study to Determine the Impact of CYP3A5 Genotype on Tacrolimus Dosing Requirements and Trough Concentrations in Heart Transplant Recipients.Semantic proximity Read ↗

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