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Article

Effects of donor-recipient combinational CYP3A5 genotypes on tacrolimus dosing in Chinese DDLT adult recipients.

International immunopharmacology - 1 Mar 2020

Liu Jianyu, Chen Dexi, Yao Bo, Guan Ge, Liu Chao, Jin Xinmin, Wang Xin, Liu Peng, Sun Yandong, Zang Yunjin

Abstract excerpt

BACKGROUND: For liver transplant (LT) recipients, the liver CYP3A5 metabolic enzymes are determined by the donor's genes, whereas the intestinal enzymes are encoded by the recipient's genes. This combinational form confuses the metabolism of tacrolimus (Tac) in vivo. This retrospective study was conducted to investigate the combined effects of donor-recipient CYP3A5 genotype on tacrolimus pharmacokinetics in...

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Identifiers

PMID: 31931373
DOI: 10.1016/j.intimp.2020.106188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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