Article
Effect of Genetic Polymorphism of CYP3A5 and CYP2C19 and Concomitant Use of Voriconazole on Blood Tacrolimus Concentration in Patients Receiving Hematopoietic Stem Cell Transplantation.
Therapeutic drug monitoring - 1 Oct 2015
Iwamoto Takuya, Monma Fumihiko, Fujieda Atsushi, Nakatani Kaname, Gayle Alberto A, Nobori Tsutomu, Katayama Naoyuki, Okuda Masahiro
Abstract excerpt
BACKGROUND: Blood tacrolimus (TAC) concentration delivered via intravenous administration is known to be influenced by genetic polymorphism of CYP3A5 and interaction with triazole antifungal agents. However, interindividual variability of blood TAC concentration is as of yet still difficult to predict during the early stages of hematopoietic stem cell transplantation (HSCT). This study was conducted to assess the...
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