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Article

Tacrolimus dosing in Chinese renal transplant recipients: a population-based pharmacogenetics study.

European journal of clinical pharmacology - 1 Aug 2011

Li Liang, Li Chuan-Jiang, Zheng Lei, Zhang Yan-Jun, Jiang Hai-Xia, Si-Tu Bo, Li Zhong-Hai

Abstract excerpt

OBJECTIVES: The aims of this study were to examine the effects of genetic and clinical factors on the maintenance dose of tacrolimus in patients following renal transplantation and to develop a tacrolimus-dosing model that could be combined with associated factors. PATIENTS AND METHODS: This study included 142 renal transplant recipients who received tacrolimus as immunosuppressive agent. CYP3A5, MDR1 and NR1I2...

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PMID: 21331500
DOI: 10.1007/s00228-011-1010-y

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