Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia.

Oncotarget - 5 Jul 2016

Poglio Sandrine, Lewandowski Daniel, Calvo Julien, Caye Aurélie, Gros Audrey, Laharanne Elodie, Leblanc Thierry, Landman-Parker Judith, Baruchel André, Soulier Jean, Ballerini Paola, Clappier Emmanuelle, Pflumio Françoise

Abstract excerpt

T cell acute lymphoblastic leukemia (T-ALL) develops through accumulation of multiple genomic alterations within T-cell progenitors resulting in clonal heterogeneity among leukemic cells. Human T-ALL xeno-transplantation in immunodeficient mice is a gold standard approach to study leukemia biology and we recently uncovered that the leukemia development is more or less rapid depending on T-ALL sample. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD34
Share to Genetic Heterogeneity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterografts

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Neoplasm Transplantation

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 27191650
DOI: 10.18632/oncotarget.9313
PMCID: PMC5173081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia.PMID 27191650Read ↗

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapseSemantic proximity Read ↗

Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Clonal evolution of acute leukemia genomes.Semantic proximity Read ↗

[Clonal evolution in leukemia].Semantic proximity Read ↗

Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment.Semantic proximity Read ↗

Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.Semantic proximity Read ↗

Tracking The Molecular Dynamics of Lineage Switch Under CD19 CAR-T Treatment in Non-KMT2A Rearranged B-ALL PatientsSemantic proximity Read ↗

The evolution of relapse of adult T cell acute lymphoblastic leukemia.Semantic proximity Read ↗

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.Semantic proximity Read ↗

Diversity of Human Leukemia Xenograft Mouse Models: Implications for Disease BiologySemantic proximity Read ↗

Evolution of leukemic heterogeneity of human B-CLL lymphocytes between and within patients.Semantic proximity Read ↗

Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.