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Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia

1 Jan 2015

Abstract excerpt

Cancer is characterized by a remarkable intertumoral, intratumoral, and cellular heterogeneity that might be explained by the cancer stem cell (CSC) and/or the clonal evolution models. CSCs have the ability to generate all different cells of a tumor and to reinitiate the disease after remission. In the clonal evolution model, a consecutive accumulation of mutations starting in a single cell results in competitive...

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PMID: 26236346
DOI: 10.1155/2015/137164

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