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Article

Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.

Cancer cell - 17 Mar 2014

Blackburn Jessica S, Liu Sali, Wilder Jayme L, Dobrinski Kimberly P, Lobbardi Riadh, Moore Finola E, Martinez Sarah A, Chen Eleanor Y, Lee Charles, Langenau David M

Abstract excerpt

Clonal evolution and intratumoral heterogeneity drive cancer progression through unknown molecular mechanisms. To address this issue, functional differences between single T cell acute lymphoblastic leukemia (T-ALL) clones were assessed using a zebrafish transgenic model. Functional variation was observed within individual clones, with a minority of clones enhancing growth rate and leukemia-propagating potential...

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Identifiers

PMID: 24613413
DOI: 10.1016/j.ccr.2014.01.032
PMCID: PMC3992437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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