Article

Tracking The Molecular Dynamics of Lineage Switch Under CD19 CAR-T Treatment in Non-KMT2A Rearranged B-ALL Patients

2024-03-29

Abstract excerpt

<title>Abstract</title> <p>Lineage switch in B-acute lymphoblastic leukemia (B-ALL) patients is a rare event during CD19 chimeric antigen receptor (CAR)-T treatment. Some studies have reported KMT2A rearrangements (KMT2A-r) as a risk factor in lineage switch, but the underlying mechanism of non-KMT2A-r cases remains unclear. Here, we described two young adult B-ALL lineage switch cases without KMT2A-r. Our analys...

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Literature Corpus work: 774a5dc6-5325-5a94-b6ac-e87ac05b2d91
DOI: 10.21203/rs.3.rs-4166024/v1

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