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Diversity of Human Leukemia Xenograft Mouse Models: Implications for Disease Biology

17 Nov 2011

Abstract excerpt

Over the past decade, xenografting human leukemia cells into mice with different levels of immunodeficiency, with or without preconditioning, has provided an important tool to study various aspects of leukemia biology and to identify distinct clinical risk groups for evaluation of novel therapeutic strategies, as well as the possibility of amplifying human leukemia cells in vivo. Interestingly, these models using...

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PMID: 22088964
DOI: 10.1158/0008-5472.can-11-1732

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