Article
A small synthetic molecule functions as a chloride-bicarbonate dual-transporter and induces chloride secretion in cells.
Chemical communications (Cambridge, England) - 31 May 2016
Liu Peng-Yun, Li Shing-To, Shen Fang-Fang, Ko Wing-Hung, Yao Xiao-Qiang, Yang Dan
Abstract excerpt
A C2 symmetric small molecule composed of l-phenylalanine and isophthalamide was found to function as a Cl(-)/HCO3(-) dual transporter and self-assemble into chloride channels. In Ussing-chamber based short-circuit current measurements, this molecule elicited chloride-dependent short-circuit current (Isc) increase in both Calu-3 cell and CFBE41o-cell (with F508del mutant CFTR) monolayers.
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