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Article

Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2016

Flores Alyssa M, Casey Scott D, Felix Christian M, Phuan Puay W, Verkman A S, Levin Marc H

Abstract excerpt

Dry eye disorders, including Sjögren's syndrome, constitute a common problem in the aging population, with limited effective therapeutic options available. The cAMP-activated Cl(-) channel cystic fibrosis transmembrane conductance regulator (CFTR) is a major prosecretory channel at the ocular surface. We investigated whether compounds that target CFTR can correct the abnormal tear film in dry eye. Small-molecule...

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Identifiers

PMID: 26842854
DOI: 10.1096/fj.201500180
PMCID: PMC4836376

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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