Article
High-throughput screening of libraries of compounds to identify CFTR modulators.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Pedemonte Nicoletta, Zegarra-Moran Olga, Galietta Luis J V
Abstract excerpt
Small molecules acting as selective activators (potentiators), inhibitors, or "correctors" of the CFTR chloride channel represent candidate drugs for various pathological conditions including cystic fibrosis and secretory diarrhea. The identification of CFTR pharmacological modulators may be achieved by screening highly diverse synthetic or natural compound libraries using high-throughput methods. A convenient...
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