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Article

Pseudohalide anions reveal a novel extracellular site for potentiators to increase CFTR function.

British journal of pharmacology - 1 Nov 2012

Li Man-Song, Cowley Elizabeth A, Linsdell Paul

Abstract excerpt

BACKGROUND AND PURPOSE: There is great interest in the development of potentiator drugs to increase the activity of the cystic fibrosis transmembrane conductance regulator (CFTR) in cystic fibrosis. We tested the ability of several anions to potentiate CFTR activity by a novel mechanism. EXPERIMENTAL APPROACH: Patch clamp recordings were used to investigate the ability of extracellular pseudohalide anions...

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Source

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Identifiers

PMID: 22612315
DOI: 10.1111/j.1476-5381.2012.02041.x
PMCID: PMC3492987

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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