Article

A Cell-Permeable Nanobody to Restore F508del Cystic Fibrosis Transmembrane Conductance Regulator Activity

2024-04-26

Abstract excerpt

Nanobodies have gained considerable attention as particularly promising biopharmaceuticals. However, nanobody-based modalities are currently limited to extracellular targets due to a lack of efficient delivery methods required to reach targets inside cells. In this study, we introduce cell-permeable nanobodies for targeting a disease-relevant intracellular protein, namely the cystic fibrosis transmembrane conducta...

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Literature Corpus work: f6853daa-15cd-505d-a15d-2a56fdc3b3bc
DOI: 10.1101/2024.04.26.591242

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