Article
CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis.
Current pharmaceutical design - 1 Jan 2006
Verkman A S, Lukacs Gergely L, Galietta Luis J V
Abstract excerpt
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a cAMP-activated chloride channel expressed in epithelia in the lung, intestine, pancreas, testis and other tissues, where it facilitates transepithelial fluid transport. In the intestine CFTR provides the major route for chloride secretion in certain diarrheas. Mutations in CFTR cause the hereditary disease cystic fibrosis, where chronic lung...
Topics
- Animals
- Antidiarrheals
- Biosensing Techniques
- Cell Line
- Chlorides
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Diarrhea
- Drug Design
- Glycine
- Humans
- Intestinal Mucosa
- Ion Channel Gating
- Ligands
- Luminescent Proteins