Article
Influence of the cytochrome P450 2D6 *10/*10 genotype on the pharmacokinetics of paroxetine in Japanese patients with major depressive disorder: a population pharmacokinetic analysis.
Pharmacogenetics and genomics - 1 Sept 2016
Nishimura Miki, Ueda Mikito, Saruwatari Junji, Nakashima Hiroo, Ogusu Naoki, Aoki Akiko, Tsuchimine Shoko, Matsuda Kazuki, Iwashita Kazuma, Ono Tatsumasa, Oniki Kentaro, Shimoda Kazutaka, Yasui-Furukori Norio
Abstract excerpt
OBJECTIVE: Although the reduced function of the cytochrome P450 2D6*10 (CYP2D6*10) allele is common among Asian populations, existing evidence does not support paroxetine therapy adjustments for patients who have the CYP2D6*10 allele. In this study, we attempted to evaluate the degree of the impact of different CYP2D6 genotypes on the pharmacokinetic (PK) variability of paroxetine in a Japanese population using a...
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