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Article

Relationship of paroxetine disposition to metoprolol metabolic ratio and CYP2D6*10 genotype of Korean subjects.

Clinical pharmacology and therapeutics - 1 May 2000

Yoon Y R, Cha I J, Shon J H, Kim K A, Cha Y N, Jang I J, Park C W, Shin S G, Flockhart D A, Shin J G

Abstract excerpt

OBJECTIVE: To evaluate the relationship between the metabolic ratio (MR) of metoprolol, CYP2D6*10B genotype, and the disposition of paroxetine in Korean subjects. METHODS: A single 40-mg dose of paroxetine was administered orally to one poor metabolizer and 15 healthy subjects recruited from 223 Korean extensive metabolizers whose phenotypes were predetermined by use of the metoprolol MR. Genotypes were...

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PMID: 10824636
DOI: 10.1067/mcp.2000.106128

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