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Article

Effect of CYP2D6*10 on pharmacokinetic variability of routinely administered metoprolol in middle-aged and elderly Japanese patients.

European journal of clinical pharmacology - 1 Sept 2003

Taguchi Masato, Nozawa Takashi, Kameyama Tomoki, Inoue Hiroshi, Takesono Chihiro, Mizukami Akiko, Hashimoto Yukiya

Abstract excerpt

OBJECTIVE: This study was performed to evaluate the effect of mutant alleles CYP2D6*2 and CYP2D6*10 on the pharmacokinetics of routinely administered metoprolol in middle-aged and elderly Japanese patients. METHODS: We determined the genotypes of CYP2D6 in 34 patients aged from 56 years to 83 years, and analyzed the plasma concentration of metoprolol at steady state after repetitive administration. The...

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PMID: 12915955
DOI: 10.1007/s00228-003-0638-7

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