Article
Dose adjustment of paroxetine based on CYP2D6 activity score inferred metabolizer status in Chinese Han patients with depressive or anxiety disorders: a prospective study and cross-ethnic meta-analysis.
EBioMedicine - 1 Jun 2024
Liao Yundan, Sun Yutao, Guo Jing, Kang Zhewei, Sun Yaoyao, Zhang Yuyanan, He Jiong, Huang Chengchen, Sun Xin, Zhang Jian-Min, Wang Jun, Wang Hua-Ning, Chen Zhi-Yu, Wang Kai, Pan Jiyang, Ni Ai-Hua, Weng Saizheng, Wang Anzhen, Cao Changbin, Sun Lidong, Zhang Yong, Kuang Li, Zhang Yunshu, Liu Zhongchun, Yue Weihua
Abstract excerpt
BACKGROUND: Understanding the impact of CYP2D6 metabolism on paroxetine, a widely used antidepressant, is essential for precision dosing. METHODS: We conducted an 8-week, multi-center, single-drug, 2-week wash period prospective cohort study in 921 Chinese Han patients with depressive or anxiety disorders (ChiCTR2000038462). We performed CYP2D6 genotyping (single nucleotide variant and copy number variant) to...
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