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Article

Nonlinear mixed effects model analysis of the pharmacokinetics of metoprolol in routinely treated Japanese patients.

Biological & pharmaceutical bulletin - 1 Oct 2004

Taguchi Masato, Nozawa Takashi, Mizumaki Kouichi, Inoue Hiroshi, Tahara Katsutoshi, Takesono Chihiro, Hashimoto Yukiya

Abstract excerpt

This study was performed to estimate the mean pharmacokinetic parameters of routinely administered metoprolol in middle-aged and elderly Japanese patients. Whole blood concentration data (65 samples) at steady-state following repetitive administration to 34 patients were analyzed using a nonlinear mixed effects model. A one-compartment model was parameterized in terms of oral clearance (CL/F) and apparent volume...

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Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2D6
Heart Failure
Metabolic Clearance Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mixed Function Oxygenases

Nonlinear Dynamics

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PMID: 15467211
DOI: 10.1248/bpb.27.1642

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