Article
Altered reward-related neural responses in non-manifesting carriers of the Parkinson disease related LRRK2 mutation.
Brain imaging and behavior - 1 Aug 2019
Thaler Avner, Gonen Tal, Mirelman Anat, Helmich Rick C, Gurevich Tanya, Orr-Urtreger Avi, Bloem Bastiaan R, Giladi Nir, Hendler Talma
Abstract excerpt
Disturbances in reward processing occur in Parkinson's disease (PD) however it is unclear whether these are solely drug-related. We applied an event-related fMRI gambling task to a group of non-manifesting carriers (NMC) of the G2019S mutation in the LRRK2 gene, in order to assess the reward network in an "at risk" population for future development of PD. Sixty-eight non-manifesting participants, 32 of which were...
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