The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing.

doi:10.1111/bdi.12068

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The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing.

Bipolar disorders - 1 Jun 2013

Heinrich Angela, Lourdusamy Anbarasu, Tzschoppe Jelka, Vollstädt-Klein Sabine, Bühler Mira, Steiner Sabina, Bach Christiane, Poustka Luise, Banaschewski Tobias, Barker Gareth, Büchel Christian, Conrod Patricia, Garavan Hugh, Gallinat Jürgen, Heinz Andreas, Ittermann Bernd, Loth Eva, Mann Karl, Martinot Jean-Luc, Paus Tomáš, Pausova Zdenka, Smolka Michael, Ströhle Andreas, Struve Maren, Witt Stephanie, Flor Herta, Schumann Gunter, Rietschel Marcella, Nees Frauke

Abstract excerpt

OBJECTIVES: Bipolar disorder is a severe mood disorder, which normally begins during adolescence or early adulthood and has a heritability of up to 80%. The largest genome-wide association analysis of bipolar disorder recently identified a new genome-wide associated variant in OZD4 (rs12576775). The aim of the present study was to further elucidate the role of this risk variant in the disease process using an...

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Psychiatric Status Rating Scales
Amygdala

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Bipolar Disorder

Corpus Striatum

Emotions

Magnetic Resonance Imaging

Membrane Glycoproteins

Reward

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PMID: 23611537
DOI: 10.1111/bdi.12068

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