The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence.

doi:10.1038/s41398-018-0184-9

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Article

The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence.

Translational psychiatry - 13 Jul 2018

Muench Christine, Schwandt Melanie, Jung Jeesun, Cortes Carlos R, Momenan Reza, Lohoff Falk W

Abstract excerpt

Alcohol dependence (AD) frequently co-occurs with major depressive disorder (MDD). While this comorbidity is associated with an increase in disease burden, worse treatment outcomes, and greater economic costs, the underlying neurobiology remains poorly understood. A recent large-scale GWAS of MDD has identified a locus in the TMEM161B-MEF2C region (rs10514299) as a novel risk variant; however, the biological...

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PMID: 30006604
DOI: 10.1038/s41398-018-0184-9
PMCID: PMC6045574

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