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Article

Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5.

Biochemical and biophysical research communications - 12 Oct 2018

Roach Brett Lee, Ngo Jordan Matthew, Limso Clariss, Oloja Koyinsola Bolutife, Bhandari Deepali

Abstract excerpt

Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase essential for embryonic development whose overactivation has been implicated in several pathologies including neurodegeneration, cancer cell metastasis and type II diabetes. Therefore, it is important to investigate molecular mechanism(s) that mediate regulation of CDK5 activity. Here we identify and characterize a novel phosphoregulatory site on CDK5....

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Identifiers

PMID: 30217452
DOI: 10.1016/j.bbrc.2018.09.017
PMCID: PMC6173645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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