Article

The Batten disease protein CLN3 is important for stress granules dynamics and translational activity

2022-05-20

Abstract excerpt

The assembly of membrane-less organelles such as stress granules (SGs) is emerging as central in helping cells rapidly respond and adapt to stress. Following stress sensing, the resulting global translational shutoff leads to the condensation of stalled mRNAs and proteins into SGs. By reorganising cytoplasmic contents, SGs can modulate RNA translation, biochemical reactions and signalling cascades to promote survi...

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Literature Corpus work: 1d34fd2b-c2a4-5af7-bef7-85fa5532d40f
DOI: 10.1101/2022.05.20.492784

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