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Article

The Role of the RNA Helicase DDX3X in Medulloblastoma Progression.

Biomolecules - 6 Jul 2024

Swarup Akanksha, Bolger Timothy A

Abstract excerpt

Medulloblastoma is the most common pediatric brain cancer, with about five cases per million in the pediatric population. Current treatment strategies have a 5-year survival rate of 70% or more but frequently lead to long-term neurocognitive defects, and recurrence is relatively high. Genomic sequencing of medulloblastoma patients has shown that DDX3X, which encodes an RNA helicase involved in the process of...

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Identifiers

PMID: 39062517
DOI: 10.3390/biom14070803
PMCID: PMC11274571

Genes

DDX3X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of the RNA Helicase DDX3X in Medulloblastoma Progression.PMID 39062517Read ↗

Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation.Semantic proximity Read ↗

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.Semantic proximity Read ↗

The variant landscape and function of DDX3X in cancer and neurodevelopmental disorders.Semantic proximity Read ↗

The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphomaSemantic proximity Read ↗

DDX3X syndrome: From clinical phenotypes to biological insights.Semantic proximity Read ↗

Differential Signaling Pathways in Medulloblastoma: Nano-biomedicine Targeting Non-coding Epigenetics to Improve Current and Future TherapeuticsSemantic proximity Read ↗

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.Semantic proximity Read ↗

RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune SignalingSemantic proximity Read ↗

Clinical and mechanistic insights into the roles of DDX41 in haematological malignancies.Semantic proximity Read ↗

SMYD3 Promotes Cell Cycle Progression by Inducing Cyclin D3 Transcription and Stabilizing the Cyclin D1 Protein in MedulloblastomaSemantic proximity Read ↗

Unwind and Relax: DDX3X RNA Helicase as a Critical Mediator of Cortical Neurogenesis.Semantic proximity Read ↗

Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis.Semantic proximity Read ↗

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