Article

Mutant forms of DDX3X with diminished catalysis form hollow condensates that exhibit sex-specific regulation

2023-03-19

Abstract excerpt

Mutations in the RNA helicase DDX3X, implicated in various cancers and neurodevelopmental disorders, often impair RNA unwinding and translation. However, the mechanisms underlying this impairment and the differential interactions of DDX3X mutants with wild-type (WT) X-linked DDX3X and Y-linked homolog DDX3Y remain elusive. This study reveals that specific DDX3X mutants more frequently found in disease form distinc...

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Literature Corpus work: 8b85e505-57d8-5c1a-b0ca-923c094408a5
DOI: 10.1101/2023.03.19.533240

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