Article
Modeling genomic diversity and tumor dependency in malignant melanoma.
Cancer research - 1 Feb 2008
Lin William M, Baker Alissa C, Beroukhim Rameen, Winckler Wendy, Feng Whei, Marmion Jennifer M, Laine Elisabeth, Greulich Heidi, Tseng Hsiuyi, Gates Casey, Hodi F Stephen, Dranoff Glenn, Sellers William R, Thomas Roman K, Meyerson Matthew, Golub Todd R, Dummer Reinhard, Herlyn Meenhard, Getz Gad, Garraway Levi A
Abstract excerpt
The classification of human tumors based on molecular criteria offers tremendous clinical potential; however, discerning critical and "druggable" effectors on a large scale will also require robust experimental models reflective of tumor genomic diversity. Here, we describe a comprehensive genomic analysis of 101 melanoma short-term cultures and cell lines. Using an analytic approach designed to enrich for...
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