Article
PDGFRA and KIT Mutation Status and Its Association With Clinicopathological Properties, Including DOG1.
Oncology research - 1 Jan 2016
Baskin Yasemin, Kocal Gizem Calibasi, Kucukzeybek Betul Bolat, Akbarpour Mahdi, Kayacik Nurcin, Sagol Ozgul, Ellidokuz Hulya, Oztop Ilhan
Abstract excerpt
Most of the gastrointestinal stromal tumors (GISTs) have gain-of-function mutations in the KIT gene, which can be used as a prognostic marker for the biological behavior of tumors, predictive marker for the response of tyrosine kinase inhibitors, and diagnostic marker. Researchers have focused on PDGFRA mutations because of both their prognostic and predictive potential and DOG1 positivity for diagnosis on GISTs....
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