Article
Mutation assay of the novel gene DOG1 in gastrointestinal stromal tumors (GISTs).
Journal of gastroenterology - 1 Jan 2008
Miwa Shigeharu, Nakajima Takahiko, Murai Yoshihiro, Takano Yasuo, Sugiyama Toshiro
Abstract excerpt
BACKGROUND: Recently, the novel gene DOG1 has been found to be overexpressed in most gastrointestinal stromal tumors (GISTs) specifically within the field of soft tissue tumors. DOG1 might play a role in development of GISTs and have potential as a diagnostic marker and therapeutic target, but the biological function and the overexpression mechanism have not yet been investigated. In this study we examined...
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