Article
DOG1 and PKC-θ are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2011
Kang Gu-Hyun, Srivastava Amitabh, Kim Young Eun, Park Hee-Jung, Park Cheol Keun, Sohn Tae Sung, Kim Sung, Kang Dae Young, Kim Kyoung-Mee
Abstract excerpt
Pathological diagnosis of gastrointestinal stromal tumors (GISTs) is based on histological findings and immunohistochemical demonstration of the KIT protein. KIT-negative GISTs account for ∼5% of cases and cause diagnostic difficulties. In the era of imatinib therapy, a correct diagnosis of GISTs is important for therapeutic reasons regardless of KIT expression. Recently, DOG1 has been introduced as an important...
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