Article
Prognostic relevance of KIT and PDGFRA mutations in gastrointestinal stromal tumors.
Anticancer research - 1 Jun 2010
Braggio Esteban, Braggio Danielle De Almeida, Small Isabele Avila, Lopes Lisandro F, Valadão Marcus, Gouveia Maria Emmerick, Moreira Aline Dos Santos, Linhares Eduardo, Romano Sérgio, Bacchi Carlos E, Renault Ilana Zalcberg, Guimarães Denise Peixoto, Ferreira Carlos Gil
Abstract excerpt
BACKGROUND: Prediction of biological behavior is crucial for selection of new therapeutic modalities in GIST. Here, we aimed to assess whether KIT and PDGFRA mutations have survival impact in gastrointestinal stromal tumors (GIST). PATIENTS AND METHODS: Fifty-five Brazilian patients with completely resected GIST were examined for KIT and PDGFRA mutations. The 5-year disease-free survival (DFS) was analyzed....
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