Article
Diverse Basis of β-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis.
PloS one - 1 Jan 2016
Okabe Hirohisa, Kinoshita Hiroki, Imai Katsunori, Nakagawa Shigeki, Higashi Takaaki, Arima Kota, Uchiyama Hideaki, Ikegami Toru, Harimoto Norifumi, Itoh Shinji, Ishiko Takatoshi, Yoshizumi Tomoharu, Beppu Toru, Monga Satdarshan P S, Baba Hideo, Maehara Yoshihiko
Abstract excerpt
AIM: β-catenin signaling is a major oncogenic pathway in hepatocellular carcinoma (HCC). Since β-catenin phosphorylation by glycogen synthase kinase 3β (GSK3β) and casein kinase 1ε (CK1ε) results in its degradation, mutations affecting these phosphorylation sites cause β-catenin stabilization. However, the relevance of missense mutations in non-phosphorylation sites in exon 3 remains unclear. The current study...
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