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Article

Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene.

Hepatology (Baltimore, Md.) - 1 Mar 2009

Cieply Benjamin, Zeng Gang, Proverbs-Singh Tracy, Geller David A, Monga Satdarshan P S

Abstract excerpt

UNLABELLED: Wnt/beta-catenin signaling plays an important role in liver development and regeneration. Its aberrant activation, however, is observed in a subset of primary hepatocellular cancers (HCCs). In the current study, we compare and contrast the tumor characteristics of HCC in the presence or absence of mutations in the beta-catenin gene (CTNNB1). Frozen HCCs (n = 32), including five fibrolamellar (FL)...

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Share to Antibody Specificity
Share to beta Catenin
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamate-Ammonia Ligase

Share to Liver Neoplasms

Share to Mutation, Missense

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 19101982
DOI: 10.1002/hep.22695
PMCID: PMC2657345

Genes

CTNNB1

Provenance

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