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Article

Hepatocellular adenomas with high-risk molecular alterations undetected by "high-risk" β-catenin and/or glutamine synthetase staining patterns.

American journal of clinical pathology - 1 Dec 2025

Gosnell Hailey L, Roberts Daniel E, Zhang Xuefeng, Azzato Elizabeth M, Jacubowski Maureen A, Toro Paula, Corredor Germán, Cheng Yu-Wei, Dermawan Josephine, Calderaro Julien, Graham Rondell P, Kakar Sanjay, Allende Daniela S

Abstract excerpt

OBJECTIVE: β-Catenin-mutated hepatocellular adenomas (HCAs) carry an increased malignant transformation risk and are screened by interpreting glutamine synthetase (GS) and β-catenin by immunohistochemistry (IHC). Our study aims to assess GS and β-catenin interpretation guidelines for applicability and reproducibility in predicting high-risk HCA and other relevant molecular alterations. METHODS: Hematoxylin and...

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Share to Adenoma, Liver Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glutamate-Ammonia Ligase

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Source

Identifiers

PMID: 41236436
DOI: 10.1093/ajcp/aqaf115

Genes

CD34
EGFR
MTOR
TERT
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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