Article

Unexpected roles for AMPK in the suppression of autophagy and the reactivation of mTORC1 signaling during prolonged amino acid deprivation

2023-12-21

Abstract excerpt

AMPK promotes catabolic and suppresses anabolic cell metabolism to promote cell survival during energetic stress, in part by inhibiting mTORC1, an anabolic kinase requiring sufficient levels of amino acids. We found that cells lacking AMPK displayed increased apoptotic cell death during nutrient stress caused by prolonged amino acid deprivation. We presumed that impaired autophagy explained this phenotype, as a pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79e6126e-c444-5158-909f-ed16dc2383ff
DOI: 10.1101/2023.12.20.572593

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unexpected roles for AMPK in the suppression of autophagy and the reactivation of mTORC1 signaling during prolonged amino acid deprivationDOI 10.1101/2023.12.20.572593Read

Contrasting views on the role of AMPK in autophagySemantic proximity Read

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.Semantic proximity Read

Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative DiseasesSemantic proximity Read

Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressorSemantic proximity Read

AMP-activated protein kinase – not just an energy sensorSemantic proximity Read

The association of AMPK with ULK1 regulates autophagy.Semantic proximity Read

Novel torin1-sensitive phosphorylation sites on the metabolic regulator AMPK revealed by label-free mass spectrometrySemantic proximity Read

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease.Semantic proximity Read

Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial diseaseSemantic proximity Read

Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein KinaseSemantic proximity Read

Nutraceuticals Modulating Mitophagy May Combat the Mitochondrial Dysfunction and Redox Stress in Several Cardiac DisordersSemantic proximity Read