Article

The interaction between aging and DNA damage influences the accumulation of APP in Alzheimer’s disease

2025-09-09

Abstract excerpt

<h4>ABSTRACT</h4> DNA damage is a major driver of the aging process, and the progression of Alzheimer’s disease (AD) worsens the situation. Neurons of the AD brain show significantly elevated levels of DNA damage compared to controls. AD is also associated with altered processing of the amyloid precursor protein (APP), best known for its Aβ proteolytic peptide fragment. In the current work we find that these thre...

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Literature Corpus work: ae523b5d-43fb-5200-96e8-7a1b7cee52fb
DOI: 10.1101/2025.09.07.674780

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