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Histone Phosphorylation in DNA Damage Response

7 Mar 2025

Abstract excerpt

The DNA damage response (DDR) is crucial for maintaining genomic stability and preventing the accumulation of mutations that can lead to various diseases, including cancer. The DDR is a complex cellular regulatory network that involves DNA damage sensing, signal transduction, repair, and cell cycle arrest. Modifications in histone phosphorylation play important roles in these processes, facilitating DNA repair...

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PMID: 40141048
DOI: 10.3390/ijms26062405

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